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ea0019oc34 | Thyroid, reproduction and endocrine tumours | SFEBES2009

Reduction of type I 5′-iodothyronine deiodinase activity and mRNA level in renal clear cell carcinoma (ccRCC): potential role of 3′ UTR and miRNA

Boguslawska JB , Master A , Piekielko-Witkowska A , Wojcicka A , Brozda I , Poplawski P , Macke-Nauman A

Type 1 deiodinase (D1) catalyses synthesis of triiodothyronine (T3) which regulates the expression of many tumor suppressor genes and oncogenes. We previously revealed that the expression of the whole pool of D1 transcripts was dramatically lowered in ccRCC tissues. One of the mechanims resulting in this aberration could be miRNA-mediated repression of target mRNAs. The aim of the study was 1) to analyze the expression of miRNA binding to 3′UTR of D1 in ccRCC; 2) ...

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Endocrine Abstracts

Reduction of type I 5′-iodothyronine deiodinase activity and mRNA level in renal clear cell carcinoma (ccRCC): potential role of 3′ UTR and miRNA

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